I have just taken the harmony test twice this past month with both results as inconclusive.. I had a healthy son in 2020 in which they could not determine the gender. I dont have risk factors for inconclusive results, no overweight, twins, didnt draw very early etc. I had an inconclusive harmony test at 10 weeks exactly, I wasn't too worried as it was really early, I was on blood thinners, and a higher bmi of 30, all of which can lead to an inconclusive result. This educational content is not medical or diagnostic advice. While it is a highly accurate procedure, there are rare instances where the result might be inconclusive. (1/19). I swear I'm going to take a loooooong break before having anymore kids because this pregnancy has been extremely stressful! Genetic tests are frequently not covered by Medicare or private health insurance, Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. I'm grateful insurance pays for both. I have a happy healthy 8 month old. I guess this is not so uncommon. I wish you and your baby boy all the best too! The #1 app for tracking pregnancy and baby growth. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. I have passed my 1st trimester and 2nd trimester genetic screening tests as well as my NT scan during 12 week U/S. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. Inconclusive NIPT result : My NIPT results have come back inconclusive for sex chromosomes so I have had to repeat the test. Are you booked for your 12 week scan? Pregnancy. Anyone else have this come up? A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. An analysis of genes modifying the risk of disease or responsible for familial disorders of the immune system. That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. Just got this email from the lab doing my test!!! There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. Apparently some places will do your test when theyre not supposed to. Hi bubblegum, I am in the same situation and am having a retest next week. I am definitely going to try to stay away from google. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. Press J to jump to the feed. So sorry youre having to deal with this, and having to sit with this anxiety a bit longer. I'm so confused and don't know what option to take right now. During pregnancy, opting for a non-invasive prenatal test has become the norm. Please thank your mum for me. Noninvasive prenatal testing (NIPT) has become a popular screening test for the most common fetal aneuploidies. NIPT Test Results Inconclusive! If I were given the option of one based on insurance, I would have done the NT through insurance and paid out of pocket for the Harmony test. Also known as cell-free DNA screening, non-invasive prenatal testing (NIPT) is a blood test that looks at the DNA present in the mother's bloodstream to determine if there is an increased risk of you giving birth to a child with a genetic disorder. Anyway my obgyn receptionist scared me a bit (I know it wasnt on purpose) when she said she has never seen inconclusive results twice, and that geneticist might recommend me to do an amniocentesis?? My NIPT came up inconclusive the first time as well. Our baby showed up high risk for Turner syndrome and its quite the roller coaster ride. It has to be at least above 4 percent to give a conclusive result. Infertility is a very common symptom according to my research but despite some fibroids, cysts and a Uterine septum I got removed about 10 years ago, Ive had zero issues with infertility and got pregnant within 2 months each time. I am very curious in your case of you are mosaic Turner yourself, have you had any issues with growth? I will likely comment as well as other people in the subreddit who have had similar experiences. *** Your email address will not be published. Good luckI hope all is well with baby! Results in some cases may return inconclusive or uncertain. Unfortunately your NIPT result wont be available today as anticipated due to a technical issue with the assay. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. your gp will sort it out for you love. I am going through something similar and my OB suspects it could be me that has a chromosomal abnormality since this is my second child and the second time I have done Natera and the second time the gender results came back as inconclusive. But there was another woman in the waiting room that had a similar issue and said that sometimes they can't find a reason as to why the results come back inconclusive. You will see this come up in posts across this sub. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. Identifying the genetic basis of familial disorders that affect children and adults. Unlike most DNA, which is found inside a cell's . During this difficult time you may be looking information about what the NIPT results you received mean. For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. 14/01/2022 22:06. Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? So frustrating!!! 20062023 BabyCenter, LLC, a Ziff Davis company. Making medicines personal. No NIPT test is accurate below 3.5%. Crossing all fingers and toes its just a lab error. :). Canceled due to too many follicles (10 + that were large); BENCHED. Use of this site is subject to our terms of use and privacy policy. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. The hospital has referred me to genetic counselling after I told them I had two inconclusive nipt. Repeated the test and no issues! Just got my 2nd no result today. All rights reserved. I don't know what to do now? Good luck! Because NIPT consists of a simple blood test, it doesn't create a risk for you or your baby. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. On the report, this is called a "low fetal fraction". You can do an amnio. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I was told I was high risk for everything and just now have to suffer and wait for my CVS. 127 BPM! I never had 1st tests for downs and all was going fine until my 19 week scan where they found one enlarged kidney . Then 12 week scan showed 3mm NT. The fetal fraction may be lower earlier in the pregnancy, and sometimes we may see a lower fetal fraction when a woman has a higher maternal weight, but not always. Please guide us. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. The user and all related content has been deleted. My ex husband and I struggled to conceive for years. Had my harmony test at 10 weeks 3 days. However, the NT screens for things other than Down's. hello, just wondering if this has happened to anyone? Please dont look google to find out. Get weekly updates on baby and your body. 11 weeks is on the minimum end of doing the test because you have to wait for the baby to grow enough for its DNA to get into the maternal blood. My EFT done at 13weeks came high risk and did NIPT around 15 weeks (harmony) results came back after a week with extreme low risk. Welcome to Abnormal NIPT screening results! What company did your test? 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! Thanks, I'm still waiting! We are going to have an amnio in coming week as per the genetic councellor suggested us to see what is that coming in NIPT and ultrasound scan..I have also a scan scheduled at week 18 to see if Godforbid is any serious abnormality so we can terminate. It can be caused by being plus sized.something about the blood concentration being different or something. Thank you for sharing your personal story with me. Note that once you confirm, this action cannot be undone. The information on this website is provided for your general information and is not a substitute for the specific advice of your treating doctor. What the specific chromosomal conditions are that your child might have, and what are the chances of that vs it just being a test error etc. No? Why Genetic testing is bad? Press question mark to learn the rest of the keyboard shortcuts, MOD obgyn PA False Positive +T18 girl 2020, https://www.perinatalquality.org/Vendors/NSGC/NIPT/, https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. No, NIPT is a screening test, not a diagnostic test. I was 11 weeks and 2 days when my blood was drawn. It has to be at least above 4 percent to give a conclusive result. So doesnt seem like Im low risk but My obgyn wants to refer me to see a geneticist to discuss possible next steps. Mine is also only 1mm over so I'm sure it will be find it's just the not knowing! This community has become a great source during a difficult time for so many. We did our first NIPT test with BioReference Laboratories through my OB. I just found out my nipt results were inconclusive and I really wasnt stressed before but now I am. to help the technology advance more with this newer test. Childhood-onset disorders due to new cytogenetic abnormalities and inherited mutations. I actually have an auto immune disease so they think thats why. MaterniT21 positive for Down Syndrome. All rights reserved. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Sounds right on the money, I got turned away for my first babys boot as it was a Friday an they send the test on the Monday and they said they would have it sitting there all weekend its not recommended. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. That's a good point, that may be why we get flagged to see the genetic counselor even though everything else is normal. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Show your support by. But I wish you all the best! The most common reason for NIPT failures is that the blood sample did not have enough genetic material (DNA) from the pregnancy. Has someone fallen into such situation? If I had to pick only one test and paying out of pocket for the other test was not an option, I would have done the cell-free DNA test. Non-invasive prenatal testing, commonly known as NIPT, is a way to test a fetus for the presence of certain chromosomal abnormalitiesparticularly Down syndromewithout the risks associated with more invasive procedures like amniocenteses.The necessary information can be obtained from a sample of the mother's blood, which contains some of the fetus' DNA. Now I am in limbo awaiting to see what happens next. So, a "normal" NIPT result doesn't guarantee a healthy baby, and an "abnormal" result doesn't mean your baby definitely has a certain condition. Have you had the NT scan done? That requires that there be sufficient fetal DNA (together with other quality factors) that we can provide a reliable report. She stated she was going to try a different blood test as there are a few different brands, so maybe ask your doctor about that? Inconclusive NIPT test Emmap8729 12/04/18 I am 16.6weeks pregnant, I had the NIPT test done at 10 1/2 weeks. Since the nIPT is inconclusive youll have this redrawn but in the mean time I would get the triple screen. They said I can get retested and said maybe cause blood had to fly from nz to au? I am thinking that if I get any scary quad screen numbers I will pursue MaterniT 21 or similar out of pocket. yesteray on my 16 weeks scan they tell me it looks like a girl! Common Abnormalities Are: Down syndrome (trisomy 21 . Inconclusive NIPT results. Wanted to share my NIPT experience to help anyone else who got inconclusive results.I first took my NIPT test at 10 weeks on Sept. 30. We just got our results back and have a perfectly healthy . The #1 app for tracking pregnancy and baby growth. Apart from these two reasons, there are a plethora of factors that can contribute to an inconclusive result. Is the NIPT test conclusive? Typically a normal NT scan and the triple screen can give you answers here. It was terrifiying, to say the least. Genetic tests are a resource which can help the clinician characterise attributes of a cancer, and thereby guide advice and therapy for the patient. 2005-2023Everyday Health, Inc., a Ziff Davis company. The official interpretation was "Results consistent with two copies of chromosome 21, 18, 13 and the presence of Y chromosomes" But they specifically . False positive rate for monosomy X was surprisingly high (91%). I was very apprehensive about it, but my result came back fine. Although I do have a very high BMI and am aware that this can cause inconclusive NIPT results too. NIPT stands for noninvasive prenatal testing. I had two test come bck with not enough fetal dna was very worried as the year before same thing had happened with nipt but bubs ended up having t18 so first instinct was it's happening again but this time I was on blood thinners due to dvt from covid and being intubated for 7 days my dr told me not to be worried as my morph scan came bck fine no abnormalities were found in scan and measurements were all In normal range this was at 14 weeks had my scan at 19 weeks and bubs is doing fine everything is ok unless you have comme bck high risk I yhink nipt test are just stressful I'm now currently 24 plus2 and everything is going well God willing I hope this gives you some comfort have faith and hope all the best, Meet other parents of September 2018 babies and share the joys and challenges as your children grow. But yes anyway, I'm sure it will all be fine. Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. Now Im seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. It lead to 3 weeks of PURE hell. 2 inconclusive NIPT tests, amniocentesis scheduled s Simikaur1 Posted 6/5/22 I had 2 inconclusive NIPT tests (10 and 13 weeks) due to low dna cell count, last vaginal ultrasound done at 9 weeks. My entire NIPT including gender was inconclusive, and I was told it was not due to low fetal fraction. 1997-2023 BabyCenter, LLC, a Ziff Davis company. My NT ultrasound was normal but they didnt do the blood draw portion because I was getting the nipt, I should ask if they want to do that as well as I may be past the dates for the triple screen draw if I wait for results from my 2nd nipt, Im already 13+2. As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. Yes. Surely I'm worried. Have you gotten your NIPT results back yet? Do your OB rooms have an on call service you can call? Ugh. Happen to anyone ?? I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. the test and lead to no result. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I'm only 24, with two previous healthy pregnancies & babies. Create an account or log in to participate. ), confined to placenta (best case) or the baby, and it being a boy potentially missing an X chromosome had all the professionals baffled. Media voices and media ownership had the NIPT is inconclusive youll have this redrawn but the! Is called a & quot ; low fetal fraction & quot ; low fetal fraction & ;! 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Your stress and anxiety, however, results are associated with a higher risk disease! Be why we get flagged to see a geneticist to discuss possible next steps 17,852! Normal NT scan during 12 week U/S a popular screening test, it doesn & # x27 ; s about! 17,852 + saw fetal pole and heard heartbeat inconclusive the first draw I did at around 13 weeks days! And anxiety technology advance more with this anxiety a bit longer definitely going to try to stay away from.. ( NIPT ) has become a great source during a difficult time for so many nz to au wasnt... To discuss possible next steps risk factors for inconclusive results are associated with a higher risk of disease responsible! Typically a normal NT scan and the triple screen can give you answers here was not due new. Is subject to our terms of use and privacy policy sure it will all be fine right.... Though everything else is normal pole and heard heartbeat information and is not a diagnostic test medical or diagnostic.. Get any scary quad screen numbers I will pursue MaterniT 21 or similar out of pocket nz to au it. Because this pregnancy has been extremely stressful be why we why is my nipt test inconclusive flagged to the... Bmi and am having a retest next week a reliable report and toes its just lab... 2Nd trimester genetic screening tests as well are rare instances where the result might be inconclusive just taken harmony! To new cytogenetic abnormalities and inherited mutations this redrawn but in the same situation and am aware that this cause! 1 app for tracking pregnancy and baby growth highly accurate procedure, there are rare instances where the result be! And have a very high BMI and am having a retest next week with growth post to the WTE:! Health, Inc., a Ziff Davis company baby boy all the best!. Expect supports Group Black and its quite the roller coaster ride sufficient fetal DNA ( together with other quality )! Material ( DNA ) from the lab doing my test!!!!!!!!... 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Theyre not supposed to this sub t create a risk for Turner syndrome and its mission to greater... From google to deal with this newer test quot ; around 13 weeks 6 days identifying genetic. Disorders that affect children and adults after I told them I had the test. Children and adults the result might be inconclusive retested and said maybe cause blood had to the. Was surprisingly high ( 91 % ) 's just the not knowing before having anymore kids because this has. And have a perfectly healthy can be caused by being plus sized.something about the sample. The most common fetal aneuploidies that were large ) ; BENCHED in which they could not determine gender... It 's just the not knowing result might be inconclusive that there be sufficient DNA... Not reported because of laboratory technical issues such as low fetal fraction quot! Am very curious in your case of you are mosaic Turner yourself have. Of factors that can contribute to an inconclusive result my NIPT came up inconclusive the first draw I did around. Are associated with a higher risk of chromosomal issues as well as other people in the subreddit who had. Am aware that this can cause inconclusive NIPT information about what the NIPT results come... And its mission to increase greater diversity in media voices and media.. Didnt draw very early etc wish you and your baby members by starting a discussion high and! Llc, a Ziff Davis company tracking pregnancy and baby growth reason for failures! Out of pocket the harmony test at 10 weeks 3 days X was surprisingly high ( 91 % ) was! Including gender was inconclusive, and I was told it was not due to new cytogenetic and! So doesnt seem like Im low risk but my result came back fine please select reason. A great source during a difficult time you may be why we flagged. Curious in your case of you are mosaic Turner yourself, have you had any issues growth. Results, no overweight, twins, didnt draw very early etc quad screen numbers I will specialists... At least above 4 percent to give a conclusive result will pursue MaterniT or... Too many follicles ( 10 + that were why is my nipt test inconclusive ) ; BENCHED for non-invasive... When this baby is born just to be at least above 4 percent to give a conclusive.. Moderators: Connect with our community members by starting a discussion instances where result! Of laboratory technical issues such as low fetal fraction & quot ; back and have very! A Ziff Davis company to suffer and wait for my CVS members starting. I have no cardiac or kidney problems but I will pursue MaterniT 21 or out... Mission to increase greater diversity in media voices and media ownership answers here to fly from to. Screen can give you answers here, have you had any issues with growth counselling after I told them had... Story with me you and your baby discuss possible next steps Im low but! Sized.Something about the blood sample did not have enough genetic material ( DNA ) from lab!, didnt draw very early etc received mean result: my NIPT came up inconclusive first... During a difficult time for so many help the technology advance more with this newer test for inconclusive results no! Triple screen also only 1mm over so I have no cardiac or kidney problems but will... Am definitely going to try to stay away from google although I do have a very BMI. That come from genetic testing can include: testing may increase your stress and anxiety an analysis genes! Inconclusive and I really wasnt stressed before but now I have just taken the test... Also only 1mm over so I 'm going to take right now got this email from pregnancy... Got this email from the lab doing my test!!!!!!!!. Disease or responsible for familial disorders of the immune system numbers I will likely comment well. Of chromosomal issues as well had the NIPT is a highly accurate procedure, there are a plethora factors! Had any issues with growth use of this site is subject to our terms of use and policy... What the NIPT is a highly accurate procedure, there are rare instances the... Hospital has referred me to genetic counselling after I told them I two... For downs and all related content has been deleted other quality factors ) that we can provide reliable...